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师资队伍

林宁

林宁，男，博士，教授，研究员，硕士研究生导师，药物化学教研室主任，药物化学学科负责人，广西壮瑶药工程技术研究中心核心成员，中国民族医药学会方药量效研究分会常务理事，中国民族医药学会医养结合分会理事，中国民族医药学会壮医药分会理事，广西、江苏、江西科技项目评估咨询专家。2010年于中山大学药学院药物化学专业博士毕业，2011年起在广西中医药大学药学院药物化学教研室从事本科及硕士研究生的《药物化学》、《药物化学专论》、《药物合成反应》、《制药工艺学》及《药学专业英语》等课程的教学工作。主持并主要参与国家及省部级科研项目10多项，其中主持国家自然科学基金3项，广西自然科学基金重点项目1项、面上项目2项，广西中医药大学中药学优势学科建设专项课题1项。在Rare Met.、Eur. J. Med. Chem.、Org. Lett.、Org. Chem. Front.、J. Org. Chem.和Cryst. Growth Des.等专业学术期刊发表SCI论文40多篇。

招生专业：药物化学、中药学

研究方向：药物分子设计合成及活性、中药有效成分修饰及活性、手性药物技术、药物绿色高效合成方法

联系方式：linning@gxtcmu.edu.cn


教研室人员信息表

近年发表的学术论文

(1)Xiao-Xuan Zeng, Jing-Sheng Lu, Dong-Wei Ma, Yu-Ting Huang, Ling Chen, Gang Wang, Qing Chen*,Ning Lin*. Application of nanoscale metal–organic frameworks in tumor immunotherapy,Rare Met.,2024, 43, 4867-4883.

(2)Jin-Zhi He, Bao-Lei Zhu, Zhen-Hui Huang, Jin-Ping Liang, Zhen-Wei Zhang*, Qing Chen*, andNing Lin*. Asymmetric Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines and Unsymmetrical Dicarbonyl-Activated Alkenes: Con-struction of 5'-Trifluoromethylated 3,2'-Pyrrolidinyl Spirooxin-doles with Three Carbonyl Groups,J. Org. Chem.2024, 89, 12924−12934.

(3)Dong-Wei Ma, Jing-Sheng Lu, Xiang-Xin Cao, Yan-Wei Cheng, Gang Wang, Zi-Qian Zhang, Bo-Cheng Chen,Ning Lin*, Qing Chen*. Zinc-based metal-organic frameworks as efficient carriers for anticancer drug to reduce toxicity and increase efficacy,Rare Met.,2024, 43, 5152-5163.

(4)Yang-Ling Li, Yan-Wei Cheng, Ying-Qi Zhang,Hui-Ling Nan,Ning Lin*, Qing Chen*. Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis,Phytochemical Analysis, 2024, 35, 1–13.

(5)Dong-Wei Ma, Gang Wang, Jing-Sheng Lu, Xiao-Xuan Zeng, Yan-Wei Cheng, Zhen-Wei Zhang,Ning Lin*, and Qing Chen*. Multifunctional nano MOF drug delivery platform in combination therapy,Eur. J. Med. Chem.,2023, 261, 115884.

(6)Feng-Ji Zhou, Bao-Lei Zhu, Zhen-Hui Huang,Ning Lin*, Zhen-Wei Zhang*. DBU-catalyzed diastereoselective 1,3-dipolar [3+2] cycloaddition of trifluoroethyl amine-derived isatin ketimines with chalcones: synthesis of 5′-CF3substituted 3,2′-pyrrolidinyl spirooxindoles,RSC Adv.,2024, 14,548–551.

(7)Wen-Run Zhu, Kai Liu, Jiang Weng*, Wei-Hua Huang, Wei-Jie Huang, Qing Chen,Ning Lin*, and Gui Lu*. Catalytic Asymmetric Synthesis of Vicinal Diamines Bearing Quaternary-Quaternary StereocentersviaUmpolung Cross-Mannich Reaction of Cyclic Ketimines,Org. Lett.2020, 22, 5014-5019.

(8)Wen-Run Zhu, Qiong Su,Ning Lin*, Qing Chen*, Zhen-Wei Zhang, Jiang Weng, Gui Lu*. Organocatalytic Synthesis of Chiral CF3-Containing Oxazolidines and 1,2-Amino Alcohols: Asymmetric oxa-1,3-Dipolar Cycloaddition of Trifluoroethylamine-Derived Azomethine Ylide,Org. Chem. Front.,2020, 7, 3452–3458.

(9)Wei-Peng Zhong, Qi-Wei Chen, Xiang-Xin Cao, Shui-Li Liu, Qing Chen,*Ning Lin*. A zinc(II) sulfate-based porous framework with new topology and its usage as catalyst in Friedel–Crafts alkylation reaction,Inorg. Chem. Commun.,2020,119, 108037.

(10) Zhen-Wei Zhang*, Shao-Wu Liu, Hong-Ping Huang, Yu-Hang Xie, Ruo-Chen Huang, Yan-Qiu Deng*,Ning Lin*. Dehydroabietane-type bifunctional organocatalysts in asymmetric synthesis: recent progress,RSC Adv.,2023, 13,31047–31058.

(11)Ning Lin*, Qiu-Xiang Wei, Li-Hua Jiang, Yan-Qiu Deng, Zhen-Wei Zhang*, Qing Chen. Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide,Catalysts,2020, 10, 14.

(12) Xiao-Qin Ma, Chong Zhuang, Bi-Chuan Wang, Yuan-Feng Huang, Qing Chen*,Ning Lin*. Cocrystal of Apigenin with Higher Solubility, Enhanced Oral Bioavailability, and Anti-inflammatory Effect,Cryst. Growth Des.,2019, 19, 5531−5537.

(13) Wen-Run Zhu, Zhen-Wei Zhang, Wei-Hua Huang,Ning Lin*, Qing Chen*, Kai-Bin Chen, Bi-Chuan Wang, Jiang Weng, Gui Lu*.Asymmetric synthesis of vicinally bis(trifluoromethyl)-substituted 3,3’-pyrrolidinyl spirooxindoles via organocatalytic 1,3-dipolar cycloaddition reactions,Synthesis,2019, 51, 1969−1979.

(14) Wen-Run Zhu, Qing Chen,Ning Lin*, Kai-Bin Chen, Zhen-Wei Zhang, Gang Fang, Jiang Weng, Gui Lu*. Organocatalytic Michael/cyclization cascade reactions of 3-isothiocyanato oxindoles with 3-trifluoroethylidene oxindoles: approach for the synthesis of 3′-trifluoromethyl substituted 3,2′-pyrrolidinyl-bispirooxindoles,Org. Chem. Front.,2018, 5, 1375−1380.

(15)Ning Lin*, Xian-wen Long, Qing Chen, Wen-run Zhu, Bi-chuan Wang, Kai-bin Chen, Cai-wu Jiang, Jiang Weng*, Gui Lu*. Highly efficient construction of chiral dispirocyclic oxindole/thiobutyrolactam/chromanone complexes through Michael/cyclization cascade reactions with a rosin-based squaramide catalyst,Tetrahedron,2018, 74, 3734–3741.

(16) Wei-Jie Huang, Qing Chen,Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong, Jiang Weng*, Gui Lu*. Asymmetric synthesis of trifluoromethylsubstituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions,Org. Chem. Front.,2017,4, 472–482.

(17) Wei-Jie Huang, Qing Chen, Wen-Run Zhu,Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Jiang Weng*, Gui Lu. Highly efficient construction of cf3-containing 3,3′-pyrrolidinyl-dispirooxindolesviabase-catalyzeddiastereoselective [3+2] annulation,Heterocycles,2017,94, 879−893.

(18)Ning Lin, Yan-Qiu Deng, Zhen-Wei Zhang, Qian Wang, Gui Lu*. Asymmetric synthesis of chiral β-hydroxy-α-amino acid derivatives by organocatalytic Aldol reaction of isocyanoesters with β, γ-unsaturated α-ketoesters,Tetrahedron: Asymmetry,2014, 25, 650–657.

(19)Lian-Qiang Wei, Yue Lia, Li-Yuan Mao, Qing Chen*,Ning Lin.A series of porous metal–organic frameworks with hendecahedron cage: Structural variation and drug slow release properties.J Solid State Chem.2018,257, 58–63.

(20)Lian-Qiang Wei,Qing Chen*, Li-Le Tang, Chong Zhuang, Wen-Run Zhu,Ning Lin,A porous metal–organic framework with a unique hendecahedron-shaped cage: structure and controlled drug release,Dalton Trans.,2016,45, 3694–3697.


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